There has been a dramatic increase in the number of community-based Staphylococcus aureus infections during the past decade. aureus reservoir is likely created, with significant linkages to the general population. ![]() Our results suggest that once a pathogen is introduced into a sociocentric network of active drug users, an identifiable community S. We found a large, linked, hidden network among participants, with no discernible clustering of closely related strains. Moreover, 27% of nominees were not drug users.Ĭonclusions. In multivariate analysis, 7 health-related and drug-use variables remained independently associated with infection. Overall strain similarity was unusually high, suggesting spread within and across networks. One third of participants were either colonized (20%) or infected (19%) with S. We identified 89 sociocentric risk networks, 1 of which contained 327 (67%) members. Participants were asked to nominate up to 10 members of their social networks, and they were invited to recruit nominees to participate. ![]() aureus carriage, and they answered a questionnaire assessing risk factors for S. Participants were screened for HIV infection and S. ![]() ![]() Of 501 individuals recruited, 485 participated. From 2003 through 2005, we recruited adult drug users in Brooklyn, New York. We combined social-network analysis and molecular epidemiology to investigate Staphylococcus aureus among drug users.
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